In Peru, Dr. Herbert West and Dr. Dan Cain are medical volunteers in a civil war with the assistant Francesca Danelli and they are researching how to create human life from dead tissue using wounded soldiers as guinea pigs. They return to Miskatonic Hospital and Dan treats a terminal patient, Gloria, and gets close to her. When the snoopy Lt. Leslie Chapham investigates the Miskatonic Massacre, he learns that body parts are missing in the morgue, and Herbert and Dan become his prime suspects. But Herbert kills the lieutenant and revives him with the serum. Meanwhile, Dr. Graves finds the head of Dr. Carl Hill and the green substance that the deceased doctor stole from Herbert, and uses the serum to resurrect Dr. Hill's head. When Gloria dies, Herbert and Dan use her head, with Meg's heart and parts of other women to create the perfect woman. But Lt. Chapham teams up with Dr. Hill to seek revenge against the crazy scientists.
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The over-the-top acting that Gordon encouraged in Re-Animator is continued here with Combs particularly adept at the darkly comic throwaway line.
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